Endocrine Abstracts

Introduction: In majority of patients with childhood-onset GH deficiency (GHD), normalisation of GH secretion at the attainment of final height (FH) is observed. However, different criteria for GHD diagnosis may be considered.The aim of the study was to compare the auxological and hormonal data of the patients with persistent and transient GHD, diagnosed according to different criteria.Patients and methods: The analysis comprised 1...

Background: Recently, vitamin D has received an enormous attention, primarily at the public health level due to its numerous biological effects. It has been suggested that vitamin D deficiency may adversely affect blood pressure and the cardiovascular system. The aim of this project was to determine the possible effects and association between vitamin D intake, blood pressure, glucocorticoids and CVD risk factors.Methods: Two pilot studies have been carr...

Introduction and Case report: Congenital adrenal hyperplasia (CAH) is a heterogenous group of conditions resulting from inborn errors of steroidogenesis, of which over 95% are due to 21-hydroxylase deficiency.We present a 15-year-old Nepalese female, who was referred to the endocrine clinic for management of CAH. This diagnosis had been at 11 months of age, whilst resident in Hong Kong, when she presented acutely with vomiting and seizures. She had since...

Introduction: Neoplastic lesions in the retroperitoneum may originate from kidneys, ureters, adrenal glands or peripheral nervous, connective, muscle and adipose tissues. Neuroendocrine tumours are exceptionally located in the retroperitoneum.The case study: A woman aged 51, with a tumour of the left adrenal gland found incidentally during an ultrasound examination of the abdominal cavity, which was performed because of dysuria. A CT confir...

The IGFs are cellular modulators that play essential roles in the regulation of growth and development processes. Obviously, the action of IGF1 is depended on the activation of the specific receptor (IGF1R), which plays pivotal role in the growth as well as in the protection of cells against different apoptotic damages.The aim of the study was to examined the effect of IGF1, acted by its receptor, on apoptosis process in mice hepatic and cardiac cells tr...

Metabolic syndrome (MS) is characterized by low-grade inflammation and determined as an increased risk for cardiovascular disease. Recently, reports have demonstrated the antiinflammatory effects of statins. Often, the inhibitor of HMG-CoA reductase called atorvastatin was used in these experiments.Therefore, the aim of the present study was to test the effect of atorvastatin (10 mg/day) on growth factors (ghrelin, IGF1) levels in piglets with MS. The ch...

Indications to GH therapy in children with short stature are still a matter of discussion.We compared first-year response to GH therapy in 80 children (62 boys, 18 girls), age 12.7±2.4 years (mean±S.D.) with different disorders of GH secretion. In all the patients nocturnal GH secretion assessed during 3 h after falling asleep was decreased (<10 ng/ml). In 40 children GH deficiency (GHD) was diagnosed on the ground of decreas...

Normal thyroid hormone secretion (or appropriate L-thyroxin substitution) is necessary for the optimal effect GH administration on growing rate. The decrease of free thyroxin (FT4) levels at GH therapy onset was reported in several studies.The aim of our study was to assess the incidence of hypothyroidism (HT) during the initial phase of GH administration in previously euthyroid children with GH deficiency (GHD) and to compare t...

Hyperprolactinemia may lead to bone loss, both due to hypogonadism and other hormonal disturbances.Aim: Aim of the study was the analysis of influences of hormonal profiles associated with hyperprolactinemia on bone mineral density (BMD) and bone turnover in women with hyperprolactinemia of various origin. The subjects were 32 patients with prolactinoma, 43 ones with functional hyperprolactinemia and 29 healthy controls. All of them were studied BMD (lum...

Background: Nocturnal profile of GH secretion is proposed to be a screening diagnostic procedure for GH deficiency (GHD) in short children. Every screening procedure must be characterised by very high sensitivity and good specificity. The data concerning the cut-off level between normal and subnormal nocturnal GH secretion are scarce and non-consistent.The aim of the study was to assess the clinical utility of 2-h nocturnal profile of GH secretion in dia...